Table 2.
Clinical characteristics at baseline and at 13 years of follow up of the female participants with and without increase in serum uric acid. The 4th (1994/95) and the 6th (2007/08) Tromsø study (n = 1367)
| Baseline 1994/95 SUA non- increasers (n = 836) | SUA Increasers (n = 531) | p-value* | Follow-up 2007/08 SUA non- Increasers (n = 836) | SUA-increasers (n = 531) | p-value** | |
|---|---|---|---|---|---|---|
| Age | 57 ± 10 | 58 ± 9 | 0.17 | 70 ± 10 | 70 ± 9 | 0.17 |
| SUA (μmol/L) | 280 ± 67 | 253 ± 57 | <0.001 | 264 ± 56 | 332 ± 74 | <0.001 |
| Estimated GFR (ml/min/1.73 m2) | 95 ± 13 | 94 ± 14 | 0.35 | 85 ± 13 | 79 ± 18 | <0.001 |
| Annual change in estimated GFR (ml/min/1.73 m2) | - | - | −0.76 ± 0.72 | −1.2 ± 0.99 | <0.001 | |
| ACR (mg/mmol) | 0.54 (0.38, 0.82) | 0.56 (0.39,0.86) | 0.42 | 0.48 (0.27, 0.87) | 0.56 (0.29, 1.16) | 0.01 |
| Mean systolic blood pressure (mmHg) | 138 ± 21 | 142 ± 23 | 0.002 | 148 ± 27 | 148 ± 25 | 1.0 |
| Hypertension, n (%) | 378 (45) | 270 (51) | 0.04 | 596 (71) | 414 (77) | 0.06 |
| Body mass index (kg/m2) | 25.5 ± 3.8 | 25.8 ± 4.1 | 0.09 | 26.3 ± 4.26 | 27.8 ± 4.8 | <0.001 |
| Cholesterol (mmol/L) | 6.73 ± 1.34 | 6.68 ± 1.27 | 0.6 | 5.88 ± 1.07 | 5.95 ± 1.17 | 0.20 |
| Current smokers, n (%) | 216 (26) | 147 (28) | 0.45 | 142 (18) | 65 (13) | 0.02 |
| Physical activity,n (%) | 179 (21) | 99 (17) | 0.04 | 192 (23) | 107 (20) | 0.5 |
| Antihypertensives incl. diuretics, n (%) | 70 (8) | 57 (11) | 0.14 | 70 (8) | 57 (10) | 0.14 |
| Diuretics, n (%) | 6 (0.7) | 7 (1.3) | 0.3 | 44 (6) | 96 (19) | <0.001 |
| Diabetes, n (%) | 14 (1.5) | 15 (2.6) | 0.15 | 75 (9) | 60 (11) | 0.2 |
| Previous myocardial infarction and/or stroke, n (%) | 25 (3) | 6 (1) | 0.002 | - | - | - |
| Started antihypertensive treatment during the observation time, n (%) | - | - | - | 230 (28) | 212 (46) | <0.001 |
| Stopped smoking during the observation time, n (%) | - | - | - | 85 (10) | 86 (16) | 0.001 |
| Became physically active during the observation time, n (%) | - | - | - | 126 (15) | 71 (13) | 0.4 |
Values presented as in Table 1. ACR: urinary albumin/creatinine ratio. P-values for differences between the SUA increasers and non-increasers at baseline* and follow-up**