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. 2015 May 14;17(11):4379–4393. doi: 10.1111/1462-2920.12863

Figure 5.

Figure 5

Virulence of P. aeruginosa PAO1-L and selected targets in a mouse model of acute lung infection in C57BL/6NCrl mice. C57BL6/NCrl 8 weeks old purchased from Charles River Laboratory were intratracheally injected with 5 × 106 CFU of PAO1-L wild type or mutants.A. Survival was monitored up to 96 h. Two independent experiments were pooled. Statistical analysis was calculated for pair wise comparisons between wild-type and mutant strains. *P < 0.05, **P < 0.01, ***P < 0.001, Mantel–Cox test.B. Lung histopathology was performed after 24 h from infection for wild-type PAO1-L, pvdQ mutant and crc mutant.C. Quantification of infiltrated areas as a percentage of total tissue area with mean ± SEM is shown. Statistical analysis was calculated for pair wise comparisons between wild-type and mutant strains. ***P < 0.001, Mann–Whitney.