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. 2015 Apr 13;87(8):696–703. doi: 10.1002/cyto.a.22671

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© 2015 The Author. Published by Wiley Periodicals, Inc, on behalf of ISAC.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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ALS specific motif as predictive toponome biomarker visualized simultaneously in ALS PBMC (a) as directly compared with healthy control (b). The motif was revealed by fully automated ICM based co-mapping of 18 cell surface proteins (c) on isolated PBMC. The motif as a whole is composed of 200 distinct CMPs. The visual field of (a) shows cells, each of which displays one ALS-specific CMP out of the whole motif (different colours). The motif contains CD16 and CD45RA as lead proteins denoted (1 = lead protein, present in all CMPs) (d), while other proteins are either not associated (0 = anticolocated), or variably associated with the lead proteins (* = wild cards) (d, motif M1) ⁶⁴^–⁶⁶. Courtesy of HUTO Project. Bar: 100 μm. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]