Table 2. Summary statistics for BMI polygenic scores (n=19,692)a.
| ADGC | GERAD | HRS | |||
|---|---|---|---|---|---|
| Variables | Cases | Controls | Total | Total | Total |
| No. (%) | 10,079 (51.2%) | 9,613 (48.4%) | 19,692 | 10,454 | 8,403 |
| BMI Polygenic Score, mean (SD) | 3.37 (0.55) | 3.36 (0.54) | 3.37 (0.55) | 4.05 (0.52) | 3.87 (0.52) |
| Mechanism-Specific BMI Polygenic Scores, mean (SD) |
|||||
| Adipogenesis | 0.63 (0.16) | 0.63 (0.17) | 0.63 (0.16) | 0.64 (0.16) | 0.57 (0.16) |
| Appetite | 1.41 (0.42) | 1.40 (0.41) | 1.41 (0.41) | 1.86 (0.42) | 1.89 (0.42) |
| Cardiopulmonary | 0.24 (0.16) | 0.23 (0.16) | 0.24 (0.16) | 0.20 (0.13) | 0.24 (0.15) |
| Unspecified Cellular Processes | 1.09 (0.25) | 1.09 (0.25) | 1.09 (0.25) | 1.34 (0.23) | 1.17 (0.22) |
a
The polygenic scores were calculated as the sum across all SNPs of the product of the allele count times the beta weights from Speliotes et al.[13] ADGC (31 SNPs), GERAD (32 SNPs), HRS (29SNPs) were used to derive the BMI polygenic score and different subset for mechanism-specific scores; for details, see Supplementary eTable 2.