Table 3. Linear regression coefficients for associations between BMI polygenic scores and measured BMI in ADGC (ACT, ROS-MAP) and HRS.
| N | β | 95% Confidence Interval |
P-value | |
|---|---|---|---|---|
| ACT + ROS-MAP | ||||
| All | 3,008 | 0.86 | (0.53, 1.20) | < 0.001 |
| Controls | 2,393 | 0.95 | (0.57, 1.33) | < 0.001 |
| AD Cases | 615 | 0.48 | (−0.18, 1.14) | 0.16 |
| ACT | ||||
| All | 1,991 | 0.51 | (0.12, 0.91) | 0.01 |
| Controls | 1,647 | 0.64 | (0.19, 1.09) | 0.01 |
| AD Cases | 344 | −0.01 | (−0.82, 0.82) | 0.99 |
| ROS-MAP: | ||||
| All | 1,017 | 1.59 | (0.98, 2.19) | < 0.001 |
| Controls | 746 | 1.7 | (0.05, 2.24) | < 0.001 |
| AD Cases | 271 | 1.15 | (0.99, 2.42) | 0.04 |
| HRS | 8403 | 1.03 | (0.83 1.23) | < 0.001 |
Abbreviations: ACT - Adult Changes in Thought Study, ROS-MAP - Rush University Religious Orders Study/Memory and Aging Project, BMI - body mass index, AD – Alzheimer’s Disease; “Controls” refers to individuals who never developed dementia during follow-up, while “AD Cases” refers to people who developed incident AD during the study period; β = difference in BMI associated with a unit change in the BMI polygenic score.