Table 5. Genetic instrumental variable effect estimates: odds ratios for associations between BMI polygenic scores and AD (ADGC, GERAD) and Dementia Probability (HRS)^a.

	Late Onset Alzheimer’s Disease									Dementia			Memory
	ADGC			GERADc			ADGC + GERADd			HRS			HRS
	Odds Ratio	95% Confidence Interval	P- value	Odds Ratio	95% Confidence Interval	P- value	Odds Ratio	95% Confidence Interval	P- value	Odds Ratio	95% Confidence Interval	P- value	Beta	95% Confidence Interval	P- value
BMI Polygenic Score	0.95	(0.90, 1.01)	0.091	0.96	(0.87, 1.07)	0.488	0.95	(0.91 ,1.00)	0.058	1.00	(0.75, 1.32)	0.98	0.002	(−0.01, 0.01)	0.57
Mechanism-Specific BMI Polygenic Scores
Adipogenesis	1.04	(0.87, 1.24)	0.700	1.26	(0.82, 1.95)	0.297	1.07	(0.90 ,1.27 )	0.450	1.05	(0.42, 2.62)	0.92	− 0.007	(−0.03, 0.02)	0.62
Appetite	0.96	(0.89, 1.03)	0.280	0.94	(0.83, 1.07)	0.381	0.96	(0.90, 1.02 )	0.160	1.02	(0.72, 1.44)	0.92	− 0.000	(−0.01, 0.01)	0.97
Cardiopulmonary Processes	1.17	(0.97, 1.42)	0.102	1.33	(0.90, 1.97)	0.152	1.21	(1.00, 1.47)	0.055	1.09	(0.42, 2.83)	0.86	0.003	(−0.03, 0.03)	0.85
Unspecified Cellular Processes	0.82	(0.72, 0.92)	0.001	0.81	(0.62, 1.06)	0.131	0.81	(0.74, 0.90 )	<0.001	0.87	(0.46, 1.66)	0.68	0.016	(−0.00, 0.04)	0.11

^aGenetic Instrumental Variable (IV) estimates (Odds Ratios and 95% Confidence Intervals) for the association between a one unit difference in BMI in polygenic scores and risk of AD / Dementia. Abbreviations: BMI – Body Mass Index, AD – Alzheimer’s Disease

^cResults from Inverse-Variance Weighted Combination of Ratio Estimates (Burgess et al.) using data from Speliotes et al. for the SNP weights and Hinney et al. for the association between SNP and AD.

^dResults from fixed effect meta-analysis.