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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: Biol Psychiatry. 2015 Jun 12;79(6):463–473. doi: 10.1016/j.biopsych.2015.06.007

Figure 4. The Met68BDNF polymorphism does not alter general compulsive-like behavior and anxiety levels in mice.

Figure 4

To assess compulsive-like behavior, the inclination of mice to make an alternative arm-entry choice in a T-Maze was measured (32, 33). In this procedure, animals learn to associate each goal arm with access to a reward (chocolate milk solution). A persistent entry into the same arm across several consecutive trials reflects an inflexible strategy to obtain the reward and represents a behavioral demonstration of compulsivity. During the test, the alternation between the two goal arms and the latency to reach the reward for each trial were measured. (A) Number of repeated arm entries before alternation designated as the first entry into the opposite goal arm). (B) Latency to reach the reward. (C–F) Anxiety-like behaviors were measured in the elevated plus maze (EPM). (C) Percentage of time spent in the open arms and (D) number of visits to the open arms. (E–F) Locomotor activity was measured by the number of entries to closed arm (E) and the total arm entries (F). Results are expressed as mean ± SEM; (A–B) n = 9 per genotype, (C–F) n=8–12 per genotype.