Table 1.
Noninvasive method for estimation of liver fibrosis | Parameters |
---|---|
Biomarkers | |
APRI | AST and platelet count |
ELF | PIIINP, TIMP-1, and hyaluronic acid |
FIB-4 | Platelet count, ALT and AST adjusted for age |
FibroIndex | platelet count, AST, and gamma-globulin |
FibroMeter | Alpha-2-macroglobulin, hyaluronic acid, platelet count, AST, prothrombin time, and urea adjusted for age |
FibroSpect II | Hyaluronic acid, TIMP-1, and alpha-2-macroglobulin |
FibroTest | Apolipoprotein A1, haptoglobin, alpha-2-macroglobulin, GGT, and total bilirubin adjusted for age and gender |
Forns index | Platelet count, GGT, and total cholesterol adjusted for age and gender |
HepaScore | Alpha-2-macroglobulin, GGT, total bilirubin, and hyaluronic acid adjusted for age and gender |
Imaging techniques | |
AixPlorer | Real-time shear wave elastography |
ARFI | Elastography |
Fibroscan | Transient elastography |
Magnetic Resonance Imaging | Elastography and water-diffusion abnormalities |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; ARFI, Acoustic Radiation Force Impulse; ELF, enhanced liver fibrosis; GGT, gamma-glutamyl transferase; PIIINP, serum amino-terminal propeptide of type III procollagen; TIMP-1, tissue inhibitors of matrix metalloproteinase.