Table 2.
Comparison of characteristics between hospital and community-based cohorts.
| Hospital-based cases (n = 55) |
Community- based cases (n = 47) |
p-value | |
|---|---|---|---|
| Female sex, n(%) | 22(40) | 23(48.9) | 0.36 |
| Age at MRI study, years (mean ± SD) | 74.7±8.5 | 83.4±10.9 | <0.001 |
| Age at pathological study, years (mean ± SD) | 75.9±9 | 87.2±10.7 | <0.001 |
| Time MRI-pathology, years (mean ± SD) | 1.2±2.8 | 3.8±2.4 | <0.001 |
| T2*-gradient-echo study, n(%) | 51(92.7)a | 47(100) | 0.06 |
| Autopsy study, n(%) | 31(56.4)b | 47(100) | <0.001 |
| Hypertension, n(%) | 35(63.6) | 37(80.4) | 0.09 |
| Antiplatelet drug users, n(%) | 22(40) | 11(28.2) | 0.07 |
| Anticoagulant users, n(%) | 6(10.9) | 3(10.7) | 0.42 |
| Pre-existing dementia, n(%) | 34(61.8) | 12(25.5) | <0.001 |
| Lobar ICH after baseline MRI, n(%) | 5(9) | 0(0) | 0.03 |
| Presence of any lobar MB, n(%) | 27(49) | 10(21.3) | 0.003 |
| Lobar MB count, median(range)c | 20(1-129) | 2(1-7) | <0.001 |
| CAA at pathological examination, n(%) | 33(60) | 22(46.8) | 0.18 |
MB=microbleed; CAA= cerebral amyloid angiopathy (defined as Vonsattel grade ≥2)
a
The remaining cases underwent susceptibility-weighted imaging
b
The remaining cases underwent brain biopsy
c
Only in individuals with strictly lobar MB