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. 2015 Jul 15;41(1):103–125. doi: 10.1038/npp.2015.178

Table 3. A Summary of the Physiological and Behavioral Action of the Different Serotonin Receptor Subtypes as Well as Their Distribution in Type I, II, and III Neurons.

Receptor Physiological action in the BNST Cell type distribution (Hazra et al, 2012)
Behavioral action
    I II III BNST CNS
5-HT1A Hyperpolarization (GIRK channels) 63% 32% 41% Anxiolytic (Levita et al, 2004; Gomes et al, 2011) Anxiolytic (Albert et al, 2014)
5-HT7 Depolarization (Gs receptor) 55% 44% 0% Unknown Depressive (Mnie-Filali et al, 2011)
5-HT2C Depolarization (Gq receptor) 5% 0% 59% Anxiogenic (Heisler et al, 2007; Marcinkiewcz et al, 2015) Anxiogenic (Heisler et al, 2007; Kimura et al, 2009)
5-HT1B Presynaptic inhibition 0% 21% 41% Unknown Aggression and impulsivity (Saudou et al, 1994; Nautiyal et al, 2015)