Figure 5.

Structural and functional connectivity of the human BNST. (a) Our structural connectivity analysis reveals anatomical connections between the BNST and multiple limbic and striatal structures, largely confirming anatomical connections in rodents (Avery et al, 2014). (b) Our resting-state functional connectivity analysis reveals a network of connections mostly overlapping with BNST anatomical connections, with the addition of a novel prefrontal cortex connection (Avery et al, 2014). Functional connections are not constrained by direct structural connections, instead providing evidence of the broader network of regions involved in accomplishing a task. (c) Importantly, the BNST functional connectivity network has been replicated in a recent study (McMenamin et al, 2014).