Table 1. The Symptomatology of PTSD and SEFL.
PTSD symptom | SEFL parallel | Source |
---|---|---|
Hyper-reactivity to mild stress, lasting at least 90 days | Increased freezing to 1 shock or loud noise | Rau et al, 2005 |
Propensity to form new fears (comorbidity with simple phobia | Increased cued and contextual fear | Rau et al, 2005 |
Anxiety | Anxiety; open field; elevated plus maze | Figure 1a and b |
Co-morbid alcohol and drug abuse | Increased voluntary alcohol consumption | Meyer et al, 2013 |
Symptoms present >30 days post trauma | >90 days | Rau and Fanselow, 2009 |
Increased startle reactivity | Hyper-reactivity to loud noise | Figure 1c and d |
Co-morbid depression | Forced swim test | Figure 1e and f |
This table displays the overlap of symptoms of SEFL and PTSD, supporting the use of SEFL as a rodent model of PTSD.