Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Nov 30;2015:917156. doi: 10.1155/2015/917156

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Said AbdAlla et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Treatment with the brain-penetrating ACE inhibitor captopril retarded signs of neurodegeneration induced by chronic mild stress. (a) Immunohistological detection of hyperphosphorylated tau protein with anti-PHF antibody in hippocampal CA3 neurons of a stressed rat without treatment (left panel) relative to a stressed rat treated with the ACE inhibitor captopril (Stressed + ACE-I) during the stress protocol (right panel); bar: 40 μm. Immunohistological experiments are representative of 4 rats/group. (b) Immunoblot detection of hyperphosphorylated tau protein (IB: PHF (AT8)) in hippocampal extracts of stressed rats without treatment relative to stressed rats treated with the ACE inhibitor captopril (Stressed + ACE-I) during the stress protocol (n = 4/group). (c) Immunoblot detection of Sncg (upper panel) and Gad65 (lower panel) in hippocampal extracts of stressed rats without treatment relative to stressed rats with ACE inhibitor (Stressed + ACE-I) treatment (n = 4/group). (d) Hippocampal Gad activity of stressed rats without treatment relative to stressed rats treated with the ACE inhibitor (Stressed + ACE-I) captopril (n = 8/group; P = 0.0002). (e) Immunoblot detection of the amyloid beta (A4) precursor protein, App (IB: App; upper panel), and β-amyloid (IB: Abeta; lower panel) in hippocampal extracts of stressed rats without treatment relative to stressed rats treated with the ACE inhibitor captopril (Stressed + ACE-I) during the stress protocol (n = 4/group).