Table 1.
Compounds | Mechanism of action | Type of CSCs | References |
---|---|---|---|
Temozolomide (TMZ) | Reversal of EMT and chemosensitizing CSCs | Glioblastoma | [27] |
STA-4783 | Targets OS by Hsp70 induction and induces ROS within CCs | Breast | [28] |
Geldanamycin | Inhibition of the TRAP1 chaperone function | Breast, lung, and neural | [31] |
Rottlerin (ROT) | Inhibitor of PI3K/Akt/mTOR pathway and inducer of apoptosis | Pancreatic | [33] |
Bardoxolone methyl | Nrf2 inhibitor | Leukemia | [34] |
Resveratrol | Wnt inhibitor | Breast | [35] |
Honokiol | Notch inhibitor | Melanoma | [36] |
Chloroquine (CQ) | Autophagy inducer | Colorectal | [37] |
Pemetrexed | Folate antagonist | Lung | [38] |
Melatonin | Induces autophagy by increasing ROS | Glioma | [39] |
Salinomycin | K+-ionophore and triggers autophagy | General CSCs | [40] |
BMD188 | Proapoptotic | Prostate cancer | [41] |
Gossypol | Hsp70 induction, ROS induction | Breast, leukemia | [42] |
PUFAs | Induces apoptosis and autophagy | Colorectal | [43] |
TrxR | ROS scavenger | Cervical | [44] |