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Difference in CSCs and CS survival after chemo-/radiotherapy. Higher apoptosis, autophagy/mitophagy, ROS, and lower metabolic activity in CSCs versus CSs may be predominant factors in explaining chemo-/radiotherapy.
| Survival properties | CCs | CSCs |
|---|---|---|
| RO/NS | ↑ | ↓ |
| Metabolic activity | ↑ | ↓ |
| Autophagy/mitophagy | ↓ | ↑ |
| Apoptosis | ↓ | ↑ |
| Chemo-/radioresistance | ↑ | ↓ |
