Figure 1.

Examples of nuclear lncRNAs interacting with chromatin regulators in ESCs. (a) The lncRNA MEG3 promotes the interaction between the EZH2 subunit of PRC2 and JARID2, thus guiding PRC2 recruitment and H3K27me3 deposition at JARID2 target sites [47]. It has also been proposed that lncRNAs specify the target site recognition of PRC2/JARID2 via RNA-DNA base-pairing (not shown) [47]. (b) lincRNA-1552 transcription is promoted by core pluripotency factors and is required for ESC self-renewal [29]. This and other transcripts positively regulate TrxG activity by binding and stabilizing the WDR5 cofactor [52].