Table 2.
Neural differentiation/development.
| Gene | Encoded protein | Fold change |
|---|---|---|
| Neural stem cells | ||
| ABCG2 | ATP-binding cassette, subfamily G (WHITE), member 2 (junior blood group) | −1.526 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | −4.911 |
| CDT1 | Chromatin licensing and DNA replication factor 1 | −1.528 |
| EGFL7 | EGF-like-domain, multiple 7 | 3.132 |
| EPHA2 | EPH receptor A2 | −1.529 |
| ETV4 | ets variant 4 | −1.934 |
| ETV5 | ets variant 5 | −2.844 |
| −2.651 | ||
| FABP7 | Fatty acid binding protein 7, brain | −2.095 |
|
| ||
| Neural differentiation | ||
| ATOH8 | Atonal homolog 8 (Drosophila) | 1.932 |
| AXL | AXL receptor tyrosine kinase | 2.015 |
| CRIM1 | Cysteine-rich transmembrane BMP regulator 1 (chordin-like) | 1.999 |
| CRLF1 | Cytokine receptor-like factor 1 | 2.382 |
| DAB1 | Dab, reelin signal transducer, homolog 1 (Drosophila) | −2.297 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | −1.613 |
| ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2 | −4.767 |
| GAP43 | Growth associated protein 43 | 1.613 |
| GLDN | Gliomedin | 5.809 |
| HMOX1 | Heme oxygenase (decycling) 1 | 1.884 |
| KLF9 | Kruppel-like factor 9 | 1.592 |
| Lmo3 | LIM domain only 3 | 1.542 |
| MAP6 | Microtubule-associated protein 6 | 1.874 |
| MYRF | Myelin regulatory factor | 2.527 |
| NEUROD4 | Neuronal differentiation 4 | 2.036 |
| OLIG1 | Oligodendrocyte transcription factor 1 | 2.660 |
| Pvr | Poliovirus receptor | 1.768 |
| RGS4 | Regulator of G-protein signaling 4 | 1.955 |
| S1PR1 | Sphingosine-1-phosphate receptor 1 | 5.073 |
| SOCS2 | Suppressor of cytokine signaling 2 | 2.052 |
| 2.335 | ||
| WIPF1 | WAS/WASL interacting protein family, member 1 | 1.587 |
|
| ||
| Neural differentiation markers | ||
| CALB2 | Calbindin 2 | 1.616 |
| CNP | 2′,3′-Cyclic nucleotide 3′-phosphodiesterase | 1.732 |
| GFAP | Glial fibrillary acidic protein | 2.239 |
| MBP | Myelin basic protein | 1.768 |
| Mturn | Maturin, neural progenitor differentiation regulator homolog (Xenopus) | 1.853 |
| OMG | Oligodendrocyte myelin glycoprotein | −1.822 |
| OPALIN | Oligodendrocytic myelin paranodal and inner loop protein | 39.246 |
| PLP1 | Proteolipid protein 1 | 1.630 |
| S100B | S100 calcium binding protein B | −1.675 |
| TUBB2A | Tubulin, beta 2A class IIa | 1.608 |
| TUBB2B | Tubulin, beta 2B class IIb | 1.535 |
| TUBB3 | Tubulin, beta 3 class III | 1.976 |
|
| ||
| Synapse and neurotransmitters | ||
| ABAT | 4-Aminobutyrate aminotransferase | −1.512 |
| ADRA1D | Adrenoceptor alpha 1D | 1.803 |
| ADRA2A | Adrenoceptor alpha 2A | 2.900 |
| ADRA2B | Adrenoceptor alpha 2B | −2.093 |
| CHRM2 | Cholinergic receptor, muscarinic 2 | 1.635 |
| CHRM3 | Cholinergic receptor, muscarinic 3 | −1.715 |
| CHRNA7 | Cholinergic receptor, nicotinic, alpha 7 (neuronal) | 1.772 |
| COMT | Catechol-O-methyltransferase | 1.515 |
| DDC | DOPA decarboxylase (aromatic L-amino acid decarboxylase) | 1.711 |
| DNM3 | Dynamin 3 | 2.643 |
| EPHA5 | EPH receptor A5 | 2.076 |
| GRIA3 | Glutamate receptor, ionotropic, AMPA 3 | −1.528 |
| GRIA4 | Glutamate receptor, ionotropic, AMPA 4 | −1.997 |
| GRIK2 | Glutamate receptor, ionotropic, kainate 2 | −1.565 |
| GRM5 | Glutamate receptor, metabotropic 5 | −1.600 |
| HTR1B | 5-Hydroxytryptamine (serotonin) receptor 1B, G-protein-coupled | −2.377 |
| HTR2B | 5-Hydroxytryptamine (serotonin) receptor 2B, G-protein-coupled | 2.205 |
| LRRTM2 | Leucine-rich repeat transmembrane neuronal 2 | 3.665 |
| LRRTM3 | Leucine-rich repeat transmembrane neuronal 3 | 2.210 |
| NTM | Neurotrimin | 1.820 |
| PENK | Proenkephalin | 3.478 |
| PRR7 | Proline rich 7 (synaptic) | 1.788 |
| SLC10A4 | Solute carrier family 10, member 4 | 1.824 |
| 1.867 | ||
| SLITRK2 | SLIT and NTRK-like family, member 2 | −2.414 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 1.672 |
| STON2 | Stonin 2 | 4.054 |
| STXBP3 | Syntaxin-binding protein 3 | 1.730 |
| Stxbp3b | Syntaxin-binding protein 3B | 1.637 |
| SV2C | Synaptic vesicle glycoprotein 2C | 1.929 |
| SYT6 | Synaptotagmin VI | 2.571 |
|
| ||
| Neurite outgrowth | ||
| ATF3 | Activating transcription factor 3 | 2.579 |
| DOK4 | Docking protein 4 | 4.937 |
| FEZ2 | Fasciculation and elongation protein zeta 2 (zygin II) | 1.547 |
| NAV2 | Neuron navigator 2 | 1.647 |
| NRCAM | Neuronal cell adhesion molecule | 2.496 |
| PLXNB3 | Plexin B3 | 1.739 |
| RGMA | Repulsive guidance molecule family member a | 1.552 |
| RNF165 | Ring finger protein 165 | −1.548 |
| ROBO2 | Roundabout, axon guidance receptor, homolog 2 (Drosophila) | −2.211 |
| SEMA3B | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted (semaphorin) 3B | 3.692 |
| SEMA3E | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted (semaphorin) 3E | 2.877 |
| SEMA4F | Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F | 4.891 |
| SEMA6A | Sema domain, transmembrane domain (TM), and cytoplasmic domain (semaphorin) 6A | −1.707 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 1.524 |
| UNC5B | unc-5 homolog B (C. elegans) | −1.927 |
|
| ||
| Growth factors | ||
| ARTN | Artemin | 2.423 |
| FGF2 | Fibroblast growth factor 2 (basic) | 2.264 |
| FGF5 | Fibroblast growth factor 5 | 7.704 |
| GDF10 | Growth differentiation factor 10 | −2.361 |
| GDF11 | Growth differentiation factor 11 | 1.604 |
| GDNF | Glial cell derived neurotrophic factor | 4.325 |
| GFRA3 | GDNF family receptor alpha 3 | 1.707 |
| MET | MET protooncogene, receptor tyrosine kinase | 6.680 |
| NGFR | Nerve growth factor receptor | 1.728 |
| NTRK3 | Neurotrophic tyrosine kinase, receptor, type 3 | −1.575 |
| SNX16 | Sorting nexin 16 | 1.641 |
| SPHK1 | Sphingosine kinase 1 | 1.704 |
| SPRY1 | Sprouty homolog 1, antagonist of FGF signaling (Drosophila) | −1.647 |