Table 2.
Demographics and PCI indications (per optimization subgroup)
| Variables | Statistic Mean ± SD (N) (Min, Max) or n/N (%) |
P-value* | |||
|---|---|---|---|---|---|
| PCI optimization without change based on OCT (n = 137) | PCI optimization based on Pre-PCI OCT only (n = 165) | PCI optimization based on post-PCI OCT only (n = 41) | PCI optimization based on pre-PCI and post-PCI OCT (n = 65) | ||
| Age (years) | 64 ± 9.9 (137) (36, 86) | 65.4 ± 10.2 (165) (37, 88) | 65.8 ± 10.7 (41) (43, 87) | 63 ± 10.4 (65) (39, 88) | 0.2825 |
| Gender | |||||
| Female | 27/137 (19.7%) | 45/165 (27.3%) | 14/41 (34.1%) | 14/65 (21.5%) | 0.1900 |
| Male | 110/137 (80.3%) | 120/165 (72.7%) | 27/41 (65.9%) | 51/65 (78.5%) | |
| BMI (kg/m2) | 28.6 ± 6.2 (135) (17.3, 52.4) | 28.5 ± 5.6 (164) (18.6, 64.7) | 33.5 ± 35.2 (41) (17.6, 246.9) | 30 ± 20.9 (65) (18, 191) | 0.2302 |
| CVA | 10/137 (7.3%) | 12/164 (7.3%) | 3/41 (7.3%) | 4/65 (6.2%) | 1.0000 |
| TIA | 3/137 (2.2%) | 0/165 (0%) | 0/41 (0%) | 1/65 (1.5%) | 0.1820 |
| Family history of CAD | 41/137 (29.9%) | 60/164 (36.6%) | 17/41 (41.5%) | 20/64 (31.3%) | 0.4385 |
| Renal insufficiency/failure | 6/137 (4.4%) | 9/164 (5.5%) | 4/41 (9.8%) | 3/65 (4.6%) | 0.5751 |
| Diabetes mellitus | 56/137 (40.9%) | 52/164 (31.7%) | 12/41 (29.3%) | 32/65 (49.2%) | 0.0462 |
| Peripheral vascular occlusive disease | 12/137 (8.8%) | 20/164 (12.2%) | 5/41 (12.2%) | 5/65 (7.7%) | 0.6521 |
| Tobacco use—smoking | 56/137 (40.9%) | 87/164 (53%) | 17/41 (41.5%) | 33/65 (50.8%) | 0.1590 |
| Hyperlipidaemia | 101/137 (73.7%) | 130/164 (79.3%) | 33/41 (80.5%) | 46/65 (70.8%) | 0.4299 |
| Taking hypertension medications at baseline | 97/137 (70.8%) | 123/165 (74.5%) | 31/41 (75.6%) | 45/65 (69.2%) | 0.7845 |
| Previous PCI in target vessel | 26/134 (19.4%) | 41/163 (25.2%) | 7/39 (17.9%) | 9/65 (13.8%) | 0.2607 |
| Previous MI | 29/134 (21.6%) | 37/163 (22.7%) | 9/39 (23.1%) | 23/65 (35.4%) | 0.1884 |
| Pre-procedure indication | |||||
| NSTEMI | 19/137 (13.9%) | 17/165 (10.3%) | 2/41 (4.9%) | 6/65 (9.2%) | 0.7273 |
| Other | 4/137 (2.9%) | 10/165 (6.1%) | 2/41 (4.9%) | 2/65 (3.1%) | |
| Stable angina | 85/137 (62%) | 97/165 (58.8%) | 29/41 (70.7%) | 44/65 (67.7%) | |
| Unstable angina | 29/137 (21.2%) | 41/165 (24.8%) | 8/41 (19.5%) | 13/65 (20%) | |
| Vessel identification | |||||
| Multi vessel | 2/138 (1.4%) | 2/168 (1.2%) | 2/42 (4.8%) | 2/69 (2.9%) | 0.0031 |
| Single vessel, multi lesion | 7/138 (5.1%) | 17/168 (10.1%) | 2/42 (4.8%) | 15/69 (21.7%) | |
| Single vessel, single lesion | 129/138 (93.5%) | 149/168 (88.7%) | 38/42 (90.5%) | 52/69 (75.4%) | |
| Target vessel (per FFR) | |||||
| Circumflex | 30/140 (21.4%) | 34/170 (20%) | 7/44 (15.9%) | 10/70 (14.3%) | 0.1624 |
| LAD | 76/140 (54.3%) | 108/170 (63.5%) | 22/44 (50%) | 45/70 (64.3%) | |
| Right | 34/140 (24.3%) | 28/170 (16.5%) | 15/44 (34.1%) | 15/70 (21.4%) | |
| Diameter stenosis (%) | |||||
| By angiography | 73.9 ± 14.7 (134) (32, 99) | 72.6 ± 15.1 (145) (0.8, 99) | 75.1 ± 12.1 (33) (44, 99) | 70.2 ± 13.4 (51) (50, 99) | 0.3683 |
*Continuous and categorical P-values were calculated using an ANOVA F-test and Fishers Exact MCMC statistics, respectively.
FFR, fractional flow reserve; OCT, optical coherence tomography; PCI, percutaneous coronary intervention.