Table 4. Docking scores of five QoI fungicides with the Qo binding site in wild-type and site-directed mutagenesis bovine heart.
Fungicide | Mean EC50(μg/ml)* | Docking scores |
||||
---|---|---|---|---|---|---|
Wild-type | S128 | C131 | A142 | S142 | ||
Azoxystrobin | 0.1228 | 11.75 | 7.93 | 5.67 | 6.14 | 6.59 |
SYP-2815 | 0.1385 | 8.95 | 5.56 | 4.10 | 4.71 | 5.36 |
SYP-1620 | 2.7234 | 7.85 | 4.87 | 4.69 | 4.70 | 4.35 |
ZJ0712 | 0.1478 | 5.99 | 5.28 | 2.23 | 4.68 | 4.10 |
Enestroburin | 0.8103 | 5.96 | 5.23 | 4.98 | 4.78 | 3.89 |
*EC50 = effective concentration for 50% inhibition of mycelial growth.