Table 1. Ion channels, transporters, and exchangers that were identified in the human ES by LC-MS/MS.
Accession number | Description (gene name) | Max coverage (%) | Max protein score |
gi|6090615 | dihydropyridine receptor alpha 2 subunit (CACNA2D1) | 13.7 | 83 |
gi|38505268 | voltage-dependent T-type calcium channel subunit alpha-1G isoform 14 (CACNA1G) | 10.5 | 72 |
gi|7630181 | alpha1A-voltage-dependent calcium channel (CACNA1A) | 3.6 | 70 |
gi|292275 | L-type voltage-dependent calcium channel (CACNA1) | 6.1 | 66 |
gi|179764 | calcium channel alpha-1D subunit (CACNA1D) | 6.2 | 64 |
gi|20070163 | voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 (CACNA1G) | 8.5 | 63 |
gi|5565888 | T-type calcium channel alpha1I subunit (CACNA1I) | 4.7 | 56 |
gi|14336738 | voltage dependent t-type calcium channel alpha-1H subunit (CACNA1H) | 5.4 | 52 |
gi|443761 | voltage-operated calcium channel; alpha-1 subunit (CACNA1E) | 7.2 | 54 |
gi|7159257 | calcium channel alpha1E subunit; delta39 splice variant (CACNA1E) | 10 | 56 |
gi|9711929 | alpha1A-voltage-dependent calcium channel (CACNA1A) | 10.3 | 55 |
gi|3183953 | L-type calcium channel alpha-1 subunit (CACNA1F) | 3.7 | 54 |
gi|55962840 | calcium channel; voltage-dependent; N type; alpha 1B subunit (CACNA1B) | 5.3 | 51 |
gi|4336152 | low-voltage activated calcium channel alpha (CACNA1H) | 4.9 | 51 |
gi|179762 | calcium channel alpha-2b subunit (CACNA2D1) | 7.1 | 51 |
gi|495868 | voltage-dependent calcium channel alpha-1E-1 (CACNA1E) | 5.6 | 50 |
gi|62088514 | calcium channel; voltage-dependent; L type; alpha 1B subunit variant (CACNA1B) | 11 | 46 |
gi|21314671 | transient receptor potential cation channel subfamily M member 4 isoform 1 (TRPM4) | 15.8 | 52 |
gi|54632969 | long transient receptor potential channel 3 (TRPM3) | 3.3 | 52 |
gi|76780233 | TRPC4 protein (TRPC4) | 5.4 | 54 |
gi|194733735 | short transient receptor potential channel 3 isoform a (TRPC3) | 7.9 | 47 |
gi|24119274 | sodium leak channel non-selective protein (NALCN) | 8.9 | 65 |
gi|189047 | Na+ channel (SCN7A) | 3.1 | 59 |
gi|25014054 | RecName: Full = Sodium channel protein type 3 subunit alpha; AltName: Full = Sodium channel protein brain III subunit alpha; (AltName: Full = Sodium channel protein type III subunit alpha; AltName: Full = Voltage-gated sodium channel subtype III; AltName: Fu (SCN3A) | 4.8 | 45 |
gi|6693697 | voltage-gated sodium channel alpha subunit SCN12A (SCN12A) | 6.9 | 45 |
gi|10334701 | apamin-sensitive small-conductance Ca2+-activated potassium channel (KCNN2) | 7.4 | 57 |
gi|186798 | voltage-gated potassium channel (KCNB1) | 10.1 | 54 |
gi|338077 | potassium channel protein (KCNC4) | 6.4 | 53 |
gi|27437001 | potassium voltage-gated channel subfamily H member 1 isoform 1 (KCNH1) | 10 | 49 |
gi|21361181 | sodium/potassium-transporting ATPase subunit alpha-1 isoform a (ATP1A1) | 9.1 | 66 |
gi|497763 | Na+; K+ -ATPase catalytic subunit (ATP1A3) | 5.4 | 45 |
gi|14286105 | RecName: Full = Plasma membrane calcium-transporting ATPase 4; Short = PMCA4; AltName: Full = Matrix-remodelling-associated protein 1; AltName: Full = Plasma membrane calcium ATPase isoform 4; AltName: Full = Plasma membrane calcium pump isoform 4 (ATP2B4) | 14.9 | 53 |
gi|118498343 | calcium-transporting ATPase type 2C member 2 (ATP2C2) | 13 | 48 |
gi|17865805 | sodium/calcium exchanger 3 isoform B precursor (SLC8A3) | 5.3 | 50 |
gi|15147254 | sodium/calcium exchanger 3 isoform A precursor (SLC8A3) | 9 | 46 |
gi|4505697 | Pendrin (SLC26A4) | 6 | 44 |
gi|68534512 | Anoctamin 6 (ANO6) | 8.7 | 52 |
Proteins searched through MASCOT (version 2.2.07) against the NCBInr database. The search parameters were: 1) Enzyme specificity - Trypsin; 2) Maximum missed cleavages - 2; 3) Carbamidomethyl (C); Oxidation (M) as variable modifications.