Table 1.
Meta-regression analysis of relationship between mean age of onset and sex ratio in phenotypes of adult-onset dystonia.
| Coefficient | SE | Z value | p Value | Confidence intervals | ||
|---|---|---|---|---|---|---|
| (A) META-REGRESSION ANALYSIS OF SEX RATIO (PROPORTION OF MEN) IN RELATION TO MEAN AGE OF ONSET OF ADULT-ONSET DYSTONIA | ||||||
| Intercept | 2.8780 | 0.4487 | 6.4141 | <0.0001 | 1.9986 | 3.7574 |
| Age of onset | −0.0709 | 0.0098 | −7.2655 | <0.0001 | −0.0900 | −0.0518 |
| (B) META-REGRESSION ANALYSIS OF SEX RATIO (PROPORTION OF MEN) IN RELATION TO DYSTONIA PHENOTYPE WITH BLEPHAROSPASM AS THE REFERENCE | ||||||
| Intercept | −0.8387 | 0.1101 | −7.6183 | <0.0001 | −1.0545 | −0.6229 |
| Cervical dystonia | 0.351 | 0.1451 | 2.42 | 0.0155 | 0.067 | 0.6353 |
| Focal hand dystonia | 1.17 | 0.17 | 6.93 | <0.0001 | 0.84 | 1.50 |
| Laryngeal dystonia | 0.047 | 0.19 | 0.243 | 0.808 | −0.33 | 0.42 |
| Musician’s dystonia | 2.30 | 0.27 | 8.50 | <0.0001 | 1.77 | 2.83 |
| (C) META-REGRESSION ANALYSIS OF SEX RATIO (PROPORTION OF MEN) IN RELATION TO BOTH MEAN AGE OF ONSET OF ADULT-ONSET DYSTONIA AND DYSTONIA PHENOTYPE WITH BLEPHAROSPASM AS THE REFERENCE | ||||||
| Intercept | 4.7640 | 1.1084 | 4.2982 | <0.0001 | 2.5916 | 6.9364 |
| Age of onset | −0.1002 | 0.0197 | −5.0840 | <0.0001 | 0.1388 | 0.0616 |
| Cervical dystonia | −1.0618 | 0.3013 | −3.5239 | 0.0004 | 1.6523 | 0.4712 |
| Focal hand dystonia | −0.4995 | 0.3556 | −1.4046 | 0.1601 | −1.1966 | 0.1975 |
| Laryngeal dystonia | −0.8752 | 0.2386 | −3.6685 | 0.0002 | 1.3429 | 0.4076 |
| Musician’s dystonia | 0.0306 | 0.5006 | 0.0611 | 0.9513 | −0.9505 | 1.0117 |
Meta-regression analysis of the two independent variables of interest: (a) mean age of onset of dystonia, (b) adult-onset dystonia phenotype, and (c) combined variables [(a) and (b)] with the sex ratio (proportion of men) as the dependent variable. Coefficients, SEs, p values, and 95% confidence intervals are shown; p values <0.05 are considered to be statistically significant.