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Effect of i.t. administration of morphine (M), hybrids 12 and 13, and the parent NK1 antagonist 5 on (A) allodynia, measured by von Frey test, and (B) hyperalgesia, measured by cold plate test, 30 min after administration in CCI-exposed rats; *p < 0.05, ***p < 0.001 vs Veh-treated CCI-exposed rats.
