Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Development of tolerance to antiallodynic effect, measured by the von Frey test (A) and antihyperalgesic effect measured by the cold plate test (B) after repeated once daily (6 days) i.t. injections of morphine (M, 3.5 nmol), hybrid compounds 12 (0.8 nmol) and 13 (1 nmol), and the NK1 parent compound 5 (2.3 nmol); *p < 0.05, **p < 0.01, ***p < 0.001 vs Veh-treated CCI-exposed rats; #p < 0.05, ##p < 0.01 vs morphine-treated CCI-exposed rats.
