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. 2015 Oct 23;6(12):1225–1230. doi: 10.1021/acsmedchemlett.5b00364

Table 1. Biochemical Activities of p97 Inhibitorsa.

entry compound/R-group p97-ADPGlo IC50 [μM] p97-ADPGlo Std. Dev. [μM]
1 12/CF3 4.7 ±2.0
2 13/SF5 21.5 ±0.4
3 23/NO2 0.05  ±0.04
4 24/CH3 0.24  ±0.11
5 25/OCH3 0.71  ±0.22
6 26/OCF3 3.8 ±0.8
a

Assay conditions: ADPGlo with 20 nM p97 ATPase WT in the presence of 100 μM ATP.37 Assays were run in quadruplicate (12, 13, 25, 26), seven times (24), or nine times (23).