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. 2015 Oct 3;18(1):58–69. doi: 10.1093/neuonc/nov244

Fig. 4.

Fig. 4.

GBM-derived EVs increase miR-21 and miR-451 levels and decrease c-Myc mRNA levels in primary mouse microglia. (A and B) Primary microglia were exposed to GBM-EVs for 24 and 48 h. Levels of miR-21 (A) and miR-451 (B) were quantitated (mean ± SEM, n = 5, ***P < .001). (C) Levels of c-Myc mRNA were measured (mean ± SEM, n = 6, *P < .05). (D) Schematic representation of 3′UTR of mouse c-Myc mRNA with miR-451 and miR-21 binding sites predicted using computational microRNA target software (http://www.microrna.org). (E and F) Levels of miR-21 (E) and miR-451 (F) in GL261 cells and EVs released from them were analyzed (mean ± SEM, n = 2).