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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Methods Mol Biol. 2016;1382:467–482. doi: 10.1007/978-1-4939-3271-9_31

Figure 3. Adenoviral-mediated transgene delivery into intracranial GBM in rodent models.

Figure 3

Microphotographs show TK expression within intracranial GBMs implanted in the rodent brain. Lewis rats bearing intracranial syngeneic CNS-1 GBMs (A) and nude mice bearing intracranial human U251 or U87 GBM (B) were intratumorally injected with Ad vectors encoding thymidin kinase (TK). TK expression was assessed by immunocytochemistry (A) and immunofluorescence (B). Nuclei were stained with DAPI (B, left panels).