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. 2015 Dec 14;6:627. doi: 10.3389/fimmu.2015.00627

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Copyright © 2015 Shen, Sanchez, Zan and Casali.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HDI upregulates the miRNAs that target Aicda. (A) Alignment of the miRNAs and their target sites in the 3′ UTR of Aicda mRNAs. (B) Expression of miRNAs that modulate AID or are predicated to modulate AID in B cells cultured with LPS plus IL-4 in the presence of HDI (VPA, 500 μM) or nil for 60 h were analyzed by miRNA-Seq and depicted as RPM. (C) Primary (pri-) miRNA transcripts of miR-155 in B cells cultured for 60 h with LPS plus IL-4 in the presence of nil or HDI were analyzed by mRNA-Seq and depicted as RPKM. Data are from three independent experiments. p values, paired t-test.