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. 2015 Dec 14;6:627. doi: 10.3389/fimmu.2015.00627

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Copyright © 2015 Shen, Sanchez, Zan and Casali.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The Prdm1 targeting miRNAs miR-23b, miR-125a, miR-351, miR-30a/c/d, miR-182, miR-96, miR-98, miR-200b/c, and miR-365 are upregulated by HDI. (A) Alignment of the 3′ UTR of Prdm1 mRNA and the targeting miRNAs. (B) Expressions of the miRNAs miR-23b, miR-125a, miR-351, miR-30a/c/d, miR-182, miR-96, miR-98, miR-200b/c, and miR-365 that target or are predicted to target Prdm1 3′ UTR, as well as miR-183, which is expressed in a same cluster with miR-182, in B cells cultured with LPS plus IL-4 in the presence of HDI (VPA, 500 μM) or nil for 60 h were analyzed by miRNA-Seq and depicted as RPM. (C) Primary (pri-) miRNA transcripts of miR-23b in B cells cultured with LPS plus IL-4 in the presence of nil or HDI for 60 h were analyzed by mRNA-Seq and depicted as RPKM. Data are from three independent experiments. p values, paired t-test.