Table 4.

Clinical Diagnostic Criteria for SRS

	Lai et al. (1994)	Price et al. (1999)	Netchine et al. (2007)	Bartholdi et al. (2009)	Dias et al. (2013)
Minimal score for clinical diagnosis of SRS	3 of 5	4 of 5	Prenatal growth retardation plus 3 of 5	8 of 15	3 of 4
Prenatal growth parameters	Birth weight ≤ −2 SD	Birth weight ≤ −2 SD	Birth weight and/or length ≤ −2 SD	Birth weight and length ≤10th ct	Birth weight < −2 SD
Postnatal growth parameters	Height ≤ −2 SD	Height ≤ −2 SD	Height ≤ −2 SD at 2 years of age	Height ≤3rd ct, normal head circumference (3rd–97th ct)	Height < −2 SD after 2 years of age
Relative macrocephaly		+	+ (at birth)	+ (at birth)	+
Body and/or limb asymmetry	+	+	+	+ (3 points)	+
Facial phenotype	Classical	Classical	Prominent forehead	Prominent forehead, triangular face and other features
Clinodactyly	+			+
Feeding difficulties			+
Normal cognitive development				+
Genital abnormalities				+
Other features				+