Table 3. IGF pathway members also display altered DNA methylation.

The total number of 120bp windows available for each gene was compared to the number of windows which were significantly differentially methylated with parity to obtain the ratio.

	Early					Late
Gene	Total Windows	Significant Windows	Ratio	Hyper	Hypo	Total Windows	Significant Windows	Ratio	Hyper	Hypo
Irs1	36	2	0.0556	0	2	35	19	0.5429	19	0
Igf1	26	3	0.1154	0	3	25	13	0.5200	12	1
Igfbp4	28	5	0.1786	1	4	20	9	0.4500	9	0
Stat5b	81	7	0.0864	3	4	85	36	0.4235	18	18
Prlr	29	3	0.1034	0	3	29	12	0.4138	12	0
Shc	21	1	0.0476	0	1	21	8	0.3810	8	0
Igfbp3	11	0	0.0000	0	0	8	3	0.3750	3	0
Igf2r	32	4	0.1250	1	3	28	10	0.3571	7	3
Igfbp6	3	0	0.0000	0	0	3	1	0.3333	1	0
Ghr	45	5	0.1111	0	5	45	14	0.3111	13	1
Akt1	22	0	0.0000	0	0	20	6	0.3000	6	0
Akt2	29	2	0.0690	0	2	29	8	0.2759	8	0
Irs2	46	10	0.2174	0	10	45	12	0.2667	12	0
Sos	27	1	0.0370	1	0	34	9	0.2647	3	6
Stat5a	16	0	0.0000	0	0	23	6	0.2609	4	2
Src	50	1	0.0200	1	0	48	10	0.2083	10	0
Stat3	51	6	0.1176	3	3	54	10	0.1852	5	5
Erk	12	0	0.0000	0	0	13	2	0.1538	2	0
Igfbp2	14	0	0.0000	0	0	12	1	0.0833	0	1
Irs4	19	0	0.0000	0	0	20	1	0.0500	1	0
Igfbp5	3	0	0.0000	0	0	3	0	0.0000	0	0
PI3K	2	0	0.0000	0	0	2	0	0.0000	0	0
Igfbp1	2	0	0.0000	0	0	2	0	0.0000	0	0