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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Aug 25;54(41):11994–11998. doi: 10.1002/anie.201505136

Scheme 3.

Scheme 3

Cross-coupling with mepacrine, and a gram scale reaction. Conditions: (a) Aryl-Cl (0.5 mmol, 1.0 equiv), vinyl-Bpin (0.53 mmol, 1.05 equiv). Sequence of addition-mixing of 16 with MeMgBr for 1 min at RT under Ar followed by sequential addition of Aryl-X with 30 sec of stirring, K3PO4 (0.18 mmol, 0.35 equiv), and Ar-Y.