Figure 6.

Effect of CP-AMPAR antagonist on impaired adaptive sensorimotor performance following intermittent nociceptive stimulation. A, INS/spinal cord training paradigm. Rats with complete thoracic spinal transection received 6 min of INS to the tail followed by intrathecal administration of the CP-AMPAR antagonist Naspm (10 mm). Spinal instrumental training task began 20 min later. B, Vehicle-treated subjects failed to exhibit a progressive increase in response duration over time, indicative of the INS-induced impairment in spinal adaptation. Naspm increased response duration over time, indicating that blocking CP-AMPAR activity protects against INS-induced maladaptive spinal plasticity. ANOVA revealed a significant increase in response duration over time in the Naspm-treated group compared to vehicle-treated animals, n = 12 subjects/per group (repeated measures, p < 0.05). Error bars represent standard error of the mean.