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. 2009 Mar 27;68(1):19–32. doi: 10.1159/000209675

Fig. 1.

Fig. 1

Adenovirus-mediated delivery of the herpes simplex virus 1 thymidine kinase gene (Ad-HSV1TK; 3 β 1010 PFU/cm3 of tumor) by a single direct injection into Eker rat uterine leiomyomata followed by subcutaneous injection of ganciclovir (GCV; 50 mg/kg/day) for 10 days significantly shrinks Eker rat uterine leiomyoma volume when compared with both Ad-LacZ/GCV and vehicle-treated animal groups. Uterine leiomyoma tumor volume was measured by both MRI scanning and caliper measurement. Tumor volume was calculated as a percentage from day 0. Each time point represents the mean ± SE of 3 animals.a, b Significant difference from control and Ad-LacZ/GCV-treated groups, respectively, at p < 0.05 using the Tukey test as a post-ANOVA test.