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. 2009 Mar 27;68(1):19–32. doi: 10.1159/000209675

Fig. 3.

Fig. 3

Ad-HSV1TK/GCV treatment modulates both apoptosis- and proliferation-related gene expression in Eker rat uterine leiomyomata. Western blot analysis of protein extracted from Eker rat uterine leiomyoma tissue treated with Ad-HSV1TK/GCV exhibited a remarkable decrease in the expressions of both the anti-apoptotic protein Bcl2 (B) and the death substrate PARP (A). Immunohistochemical analysis of Eker rat uterine leiomyoma sections treated with Ad-HSV1TK/GCV revealed a significant increase in the pro-apoptotic Bax protein at all time points (C, D). Western blot analysis of the same tissue samples revealed that the Ad-HSV1TK/GCV treatment resulted in a decrease in proliferation-regulating gene expression, cyclin D1 (E) and proliferating nuclear antigen (PCNA; F).a, b Significant difference from control and Ad-LacZ/GCV-treated animals, respectively, at p < 0.05 using the Tukey test as a post-ANOVA test.