Figure 1.

Summary of nintedanib.

Notes: (A) Molecular structure of nintedanib. (B) In vitro kinase inhibition profile of nintedanib (IC₅₀). Data presented as mean ± standard error of at least three determinations.

Abbreviations: VEGFR, vascular endothelial growth factor receptor; FGFR, fibroblast growth factor receptor; PDGFR, platelet-derived growth factor receptor; IGF1R, insulin-like growth factor 1 receptor; InsR, insulin receptor; Flt-3, fms-like tyrosine protein kinase 3; Lck, lymphocyte-specific tyrosine kinase; Src, proto-oncogene tyrosine protein kinase src; Lyn, tyrosine-protein kinase lyn; EGFR, epidermal growth factor receptor; HER2, human epidermal growth factor receptor 2; CDK, cyclin-dependent kinase.