Table 3.
CML patients’ self-reported ADRs compared to their adherence to TKIs measured by MMAS (n=86)
| ADRs | Total (n=86) n (%) |
MMAS score 8 (n=20) (high adherence) n (%) |
MMAS score 6–7.75 (n=48) (medium adherence) n (%) |
MMAS score <6 (n=18) (low adherence) n (%) |
|---|---|---|---|---|
| Muscle soreness or cramping | 69 (100) | 15 (22) | 39 (57) | 15 (22) |
| Swelling of hands, legs, feet, or around the eyes | 59 (100) | 14 (24) | 35 (59) | 10 (17) |
| Fatigue | 43 (100) | 11 (26) | 19 (44) | 13 (30) |
| Diarrhea | 35 (100) | 10 (29) | 21 (60) | 4 (11) |
| Nausea | 35 (100) | 7 (20) | 21 (60) | 7 (20) |
| Having a dry mouth | 34 (100) | 8 (24) | 20 (59) | 6 (18) |
| Bruising easily | 29 (100) | 9 (31) | 17 (59) | 3 (10) |
| Rashes or skin changes | 29 (100) | 6 (21) | 15 (52) | 8 (28) |
| Numbness or tingling | 24 (100) | 8 (33) | 12 (50) | 4 (17) |
| Disturbed sleep | 18 (100) | 5 (28) | 8 (44) | 5 (28) |
| Feeling of being distressed | 18 (100) | 2 (11) | 13 (72) | 3 (17) |
| Problem with remembering things | 18 (100) | 5 (28) | 11 (61) | 2 (11) |
| Feeling sad | 18 (100) | 3 (17) | 10 (56) | 5 (28) |
| Feeling malaise | 16 (100) | 5 (31) | 7 (44) | 4 (25) |
| Lack of appetite | 15 (100) | 4 (27) | 7 (47) | 4 (27) |
| Pain | 15 (100) | 3 (20) | 9 (60) | 3 (20) |
| Vomiting | 15 (100) | 2 (13) | 12 (80) | 1 (7) |
| Feeling drowsy | 14 (100) | 3 (21) | 7 (50) | 4 (29) |
| Shortness of breath | 13 (100) | 4 (31) | 6 (46) | 3 (23) |
Abbreviations: ADRs, adverse drug reactions; CML, chronic myeloid leukemia; TKI, tyrosine kinase inhibitor; MMAS, Morisky’s 8-item Medication Adherence Scale.