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. 2015 Dec 14;10(12):e0144983. doi: 10.1371/journal.pone.0144983

Fig 1. High-fat diet induced insulin resistance in tga20 mice.

Fig 1

(A) Left: Body weight of tga20 mice fed with either high-fat diet (HFD) or normal diet (ND). After 4 weeks, HFD-fed mice gained significantly more body weight than ND-fed mice after 4 weeks. (n = 6; ***: p<0.001). Right: appearance of mice fed with ND or HFD for 4 weeks. (B) Fasting glucose and insulin level in HFD-fed and ND-fed mice. HFD-fed mice had similar levels of fasting glucose, but showed significantly higher fasting insulin levels. (n = 6; n.s: p>0.05; **: p<0.01). (C) glucose tolerance test and (D) insulin tolerance test of HFD-fed and ND-fed mice. HFD-fed mice showed impaired response to intraperitoneally injected glucose and insulin (n = 6; ***: p<0.001; ****: p<0.0001).