Fig. 3.

Reduction in radionuclide-derived early left ventricular diastolic filling with age at rest and during maximal upright cycle exercise in healthy BLSA volunteers. The decline in peak filling rate with age was significant, both at rest and during exercise, r = − 0.64, P \ 0.05, for each condition. The inset displays a typical transmitral Doppler echocardiographic flow profile of a young and older adult (from reference 34)