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. Author manuscript; available in PMC: 2015 Dec 14.
Published in final edited form as: Dev Dyn. 2010 Mar;239(3):855–864. doi: 10.1002/dvdy.22220

Figure 8. Morphogenesis of the intrahepatic biliary network.

Figure 8

Confocal projections through the liver that was dissected from a 76 hpf Notch reporter larvae and cultured for 4.5 hours. Numbers in lower right corner indicate duration of culture in minutes. (A) These images show progressive lengthening and then shortening of the cytoplasmic bridge between two adjacent biliary cells (arrows). Fusion of cytoplasmic vesicles leading to the formation of a ductal lumen within two adjacent cells is also evident (arrowheads). (B) These images show the migration of a single biliary cell via a cytoplasmic extension (arrows). (C) These images show the dynamic pattern of filopodia extension and retraction from two biliary cells (arrows and arrowheads).