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. 2014 Aug 21;26(1):180–191. doi: 10.1093/cercor/bhu190

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Figure 3. — Endogenous D₄R activation induced different effects on sAP frequency in PFC pyramidal neurons and PV+ interneurons. (A) The time course of normalized sAP frequency showing the effect of dopamine transporter inhibitor GBR-12909 (10 μm), in the presence of D_1/5 antagonist SCH23390 (10 μm) and D_2/3 antagonist sulpiride (5 μm), in PFC pyramidal neurons (triangle unfilled) and PV+ interneurons (round filled). (B,C) Representative traces of sAP at different time points (denoted by a–c) in plot A. Scale bars: 20 mV, 1 s. (D) Bar graph summary of percentage change of sAP frequency by GBR-12909 (in the presence of SCH23390 and sulpiride) in PFC pyramidal neurons and PV+ interneurons.