Figure 6.

D₄R agonist PD168077 had not effect on the intrinsic excitability. (A,C) Representative traces of action potentials evoked by injected currents (20 s/pulse) before and after PD168077 (40 μm) application in a PFC pyramidal neuron (A) and a PV+ interneuron (C). Scale bars: 20 mV, 50 m. (B,D) The time course of evoked AP frequency showing the lack of effect of PD168077 in a PFC pyramidal neuron (B) and a PV+ interneuron (D). (E) Bar graph summary of the percentage change of evoked AP frequency by PD168077 in PFC pyramidal neurons and PV+ interneurons.