Table 2.
Spontaneous EPSC and IPSC amplitudes and event numbers before (control) and after PD168077 application in PFC pyramidal neurons and PV+ interneurons
| Pyramidal | Total |
Big |
Total |
Big |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amplitude (pA) |
Amplitude (pA) |
Events (1 min) |
Events (1 min) |
|||||||||
| Control | PD | Control | PD | Control | PD | Control | PD | |||||
| sEPSC | ||||||||||||
| Cell 1 | 10.5 | 9.3 | 13.9 | 11.1 | 231 | 205 | 72 | 40 | ||||
| Cell 2 | 10.8 | 9.9 | 14.8 | 11.9 | 126 | 110 | 49 | 35 | ||||
| Cell 3 | 11.1 | 10.6 | 16.3 | 13.1 | 305 | 279 | 95 | 69 | ||||
| Cell 4 | 13.4 | 11.2 | 18.5 | 12.5 | 189 | 161 | 68 | 32 | ||||
| Cell 5 | 12.1 | 10.2 | 19.4 | 15.4 | 210 | 182 | 69 | 47 | ||||
| Cell 6 | 9.8 | 8.3 | 13.5 | 10.8 | 119 | 102 | 43 | 32 | ||||
| Cell 7 | 13.6 | 12.1 | 17.7 | 12.1 | 172 | 165 | 65 | 41 | ||||
| sIPSC | ||||||||||||
| Cell 1 | 15.6 | 13.5 | 23.7 | 19.1 | 358 | 317 | 129 | 95 | ||||
| Cell 2 | 21.6 | 18.4 | 32.5 | 25.3 | 452 | 392 | 178 | 119 | ||||
| Cell 3 | 19.4 | 17.4 | 29.8 | 24.1 | 268 | 236 | 86 | 60 | ||||
| Cell 4 | 18.7 | 17.2 | 31.7 | 26.6 | 327 | 295 | 117 | 90 | ||||
| Cell 5 | 16.3 | 14.5 | 27.2 | 19.2 | 294 | 253 | 105 | 68 | ||||
| Cell 6 | 20.1 | 18.2 | 30.4 | 22.1 | 392 | 346 | 141 | 103 | ||||
| Cell 7 | 19.7 | 16.8 | 28.1 | 20.6 | 303 | 310 | 119 | 72 | ||||
| PV+ | Total | Big | Total | Big | ||||||||
| Amplitude(pA) | Amplitude(pA) | Events (1 min) | Events (1 min) | |||||||||
| Control | early | late | Control | early | late | Control | early | late | Control | early | late | |
| sEPSC | ||||||||||||
| Cell 1 | 16.5 | 18.1 | 14.2 | 26.5 | 31.6 | 20.1 | 402 | 443 | 351 | 129 | 171 | 100 |
| Cell 2 | 14.3 | 15.1 | 12.6 | 23.7 | 28.0 | 19.4 | 347 | 377 | 307 | 111 | 147 | 78 |
| Cell 3 | 17.8 | 20.6 | 16.9 | 26.3 | 33.6 | 21.5 | 289 | 328 | 266 | 97 | 144 | 78 |
| Cell 4 | 15.6 | 16.6 | 13.5 | 23.4 | 27.7 | 19.1 | 341 | 365 | 294 | 123 | 155 | 88 |
| Cell 5 | 15.7 | 17.8 | 15.0 | 23.9 | 29.7 | 19.6 | 325 | 364 | 299 | 106 | 154 | 84 |
| Cell 6 | 17.2 | 18.9 | 15.3 | 26.4 | 32.1 | 21.5 | 344 | 389 | 332 | 113 | 139 | 81 |
| Cell 7 | 18.3 | 19.8 | 16.6 | 28.3 | 35.5 | 22.2 | 433 | 488 | 411 | 138 | 194 | 103 |
| sIPSC | ||||||||||||
| Cell 1 | 14.2 | 12.5 | 15.2 | 25.1 | 18.0 | 30.2 | 364 | 319 | 416 | 117 | 88 | 174 |
| Cell 2 | 15.1 | 14.1 | 17.2 | 24.1 | 19.3 | 32.4 | 369 | 339 | 409 | 123 | 76 | 173 |
| Cell 3 | 14.3 | 13.2 | 16.1 | 24.6 | 19.4 | 30.4 | 236 | 214 | 259 | 84 | 48 | 108 |
| Cell 4 | 17.6 | 15.2 | 19.0 | 27.7 | 19.1 | 33.1 | 128 | 111 | 145 | 43 | 29 | 66 |
| Cell 5 | 14.8 | 13.2 | 16.2 | 26.5 | 20.6 | 32.1 | 168 | 158 | 180 | 57 | 44 | 84 |
| Cell 6 | 16.9 | 15.6 | 18.1 | 27.7 | 21.9 | 32.6 | 328 | 298 | 401 | 98 | 64 | 138 |
| Cell 7 | 18.2 | 17.2 | 20.8 | 31.2 | 24.8 | 35.7 | 378 | 334 | 434 | 121 | 83 | 159 |
Averaged values of the total synaptic events and the subpopulation of “big” synaptic events (with amplitudes bigger than the mean) in each cell are included.