Figure 7.

Scheme depicting how prenatal MAU^ab impacts precursor cell function during development of the cerebral cortex. RG cells detach from the ventricle and translocate their soma from the VZ into the overlying SVZ. However, the stage of development at which RG cells translocate into the SVZ is tightly regulated and varies by species. (A) In mouse, Pax6+ RG cells begin translocating from the VZ during later stages of neurogenesis. (B) In macaque, RG cells begin translocating into the SVZ soon after the start of neurogenesis. (C) In the prenatal mouse neocortex that has been exposed to MAU^ab, RG cells precociously detach from the ventricle and translocate away from the VZ into the SVZ much earlier than normal. Prenatal treatment with MAU^ab produces RG translocation in the mouse at nearly the same stage of cortical development as occurs in the macaque, changing the normal pattern and timing of the neurogenic process.