Figure 2.

Maturational changes in the temporal characteristics and amplitude of the identified functional brain activity (a). The lag time to the positive peak of the identified response decreases systematically with increasing PMA (data shown with robust regression line with prediction error bands). (b) The amplitude of BOLD signal change within the identified clusters of activity are significantly higher at the conclusion of the third trimester (35–36 weeks PMA) in comparison to younger infants and those at term equivalent age (line represents data median; box represents data lower and upper quartile; *P < 0.05 Mann–Whitney U-test with Holm–Bonferroni correction).