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. 2015 Oct 15;26(1):414–426. doi: 10.1093/cercor/bhv227

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© The Author 2015. Published by Oxford University Press

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — M1R-induced EPSP enhancement is NMDAR dependent. (A) The NMDAR antagonist D-AP5 (50 µm) prevented the increase in EPSP amplitude induced by application of GSK-5 (500 nm) in whole-cell current clamp recordings. (B) Application of D-AP5 (50 µm) after GSK-5 (500 nm) failed to reverse the increase in EPSP amplitude induced by GSK-5. Data plotted as mean ± s.e.m. Example voltage traces in response to synaptic stimulation taken from Points 1 or 2 as indicated. Scale bars: 2 mV and 50 ms (A,B).