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. Author manuscript; available in PMC: 2015 Dec 14.
Published in final edited form as: ACS Appl Mater Interfaces. 2015 Jun 9;7(24):13693–13700. doi: 10.1021/acsami.5b03619

Figure 2.

Figure 2

(A) ELISA results showing β amyloid capture efficiency from infected blood samples using anti-β amyloid antibody attached plasmonic-magnetic hybrid graphene oxide based nanoplatform. Plots also show that separation efficiency is less than 3% in the absence of anti-β amyloid antibody. (B) Spectrum showing SERS intensity from β amyloid conjugated nanoplatform after magnetic separation. Observed SERS signal is directly from the β amyloid. Other than D and G bands, no SERS signal was observed when whole blood without β amyloid was used. (C) Plot showing how SERS amide I band intensity from β amyloid conjugated nanoplatform changes with concentration between 0 and 6 pg/mL. Our experimental data show that the detection efficiency can be as low as 500 fg/mL.