Skip to main content
. Author manuscript; available in PMC: 2015 Dec 14.
Published in final edited form as: ACS Appl Mater Interfaces. 2015 Jun 9;7(24):13693–13700. doi: 10.1021/acsami.5b03619

Figure 3.

Figure 3

(A) ELISA results showing tau protein capture efficiency from an infected blood sample using anti-tau antibody attached plasmonicmagnetic hybrid graphene oxide based nanoplatform. Plots also show that separation efficiency is less than 4% in the absence of anti-tau antibody. (B) Spectrum showing SERS intensity from tau protein conjugated nanoplatform after magnetic separation. Observed SERS signal is directly from the tau protein. (C) Concentration dependent SERS spectra from tau protein conjugated nanoplatform after magnetic separation. Our experimental data show that the detection efficiency can be as low as 100 fg/mL. (D) Plot showing SERS enhancement of Raman signal from 50 ng tau protein in the presence of core–shell nanoparticle and from 500 ng tau protein in the presence of core–shell nanoparticle attached graphene oxide hybrid.