Kv1.2 potassium channel: A) Volume visualization in UCSF Chimera [21]. B) Image from Protein Data Bank Japan (PDBj). C through F show reconstructions from clean images - C) OE with α4 known, D) OE with β4 known, E) OR with α4 known, and F) OE with β4 known. G through J show reconstructions from noisy images using OR - G) SNR=0.7 with α4 known, H) SNR=0.7 with β4 known, I) SNR=0.35 with α4 known, and J) SNR=0.35 with β4 known.