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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Jun 14;1863(3):382–391. doi: 10.1016/j.bbamcr.2015.05.036

Fig. 3.

Fig. 3

Hypoxia induces collagen deposition and fiber formation that stiffen the extracellular matrix (ECM). Hypoxia also induces RhoA/ROCK1-mediated myosin light chain (MLC) phosphorylation and focal adhesion kinase (FAK) activity that are required for actin-myosin contractility and cell motility on stiff ECM. Blue oval, protein encoded by a HIF target gene; purple oval, protein that is regulated by HIF-dependent RhoA/ROCK1 signaling.