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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Jun 14;1863(3):382–391. doi: 10.1016/j.bbamcr.2015.05.036

Fig. 4.

Fig. 4

HIF-1 induces transcription of the WWTR1 and SIAH1 genes to increase TAZ expression and activity in hypoxic breast cancer cells. WWTR1 encodes TAZ, whereas SIAH1 encodes a ubiquitin protein ligase that targets LATS2 for proteasomal degradation, thereby eliminating a negative regulator of TAZ nuclear localization and transcriptional activity.